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            Adjeroh, Donald A; Zhou, Xiaobo; Derevyanchuk, Ekaterina G; Shkurat, Tatiana P; Martinez, Ivan; Lipovich, Leonard (Ed.)This is a mini-review capturing the views and opinions of selected participants at the 2021 IEEE BIBM 3rd Annual LncRNA Workshop, held in Dubai, UAE. The views and opinions are expressed on five broad themes related to problems in lncRNA, namely, challenges in the computational analysis of lncRNAs, lncRNAs and cancer, lncRNAs in sports, lncRNAs and COVID-19, and lncRNAs in human brain activity.more » « less
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            Taylor, Andrew D; Hathaway, Quincy A; Kunovac, Amina; Pinti, Mark V; Newman, Mackenzie S; Cook, Chris C; Cramer, Evan R; Starcovic, Sarah A; Winters, Michael T; Westemeier-Rice, Emily S; et al (, American Journal of Physiology-Cell Physiology)Long noncoding RNAs (lncRNAs) are relatively novel RNAs with increasingly prominent roles in regulating genetic expression, mainly in the nucleus but more recently in regions such as the mitochondrion. This study explores how lncRNAs interact with polynucleotide phosphorylase (PNPase), a protein that regulates RNA import into the mitochondrion. Machine learning identified several RNA structural features that improved lncRNA binding to PNPase, which may be useful in targeting RNA therapeutics to the mitochondrion.more » « less
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